TESTOSTERON (I)

Testosteron is een geslachtshormoon dat wordt gemaakt in de testes en de bijnieren. Mannen hebben (als het goed is) veel meer testosteron dan vrouwen: het wordt dan ook een 'mannelijk geslachtshormoon' genoemd. Een te hoog of juist een te laag testosteron kan diverse lichamelijke gevolgen hebben. Nu even over het psychische vlak. 203 mannen tussen de 71 en 89 jaar met en depressie werden onderzocht. Ze werden vergeleken met een groep niet-depressieve mannen. Bij de groep met een depressie bleek sprake van een significant lagere concentratie testosteron in het bloed. Opvallend was dat de groep mannen met een depressie eveneens vaker rookte en een hoger gewicht hadden. Hun lichamelijke conditie was ook slechter. Bovendien bleek dat ze significant lager scoorden op de MMSE, een scorelijst voor cognitieve achteruitgang (dus er was bij deze mannen meer cognitieve achteruitgang). De meesten hadden (begrijpelijkerwijs) in het verleden al eerder antidepressiva gebruikt. Toch, als werd gecorrigeerd voor deze factoren, bleef staan dat het risico op een depressie verband hield met een verlaagd testosteron. (Arch Gen Psych '08;65:283-9) Hoe komt dit verband? En zou het toedienen van testosteron aan deze mannen een verbetering vd depressieve klachten geven? Dat is voer voor vervolg onderzoek. En what about cortisol? Wordt morgen, of overmorgen reeds vervolgd.

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Cub Confabula WIKI over stemmingsstoornissen
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21 Apr '08

6 opmerkingen:

Remko zei

Hoewel sommige pilsreclames ons anders willen doen geloven is het nog niet zover, maar volgens mij is het dus een goed idee testosteron aan bier toe te voegen. Of in ieder geval een placebo ;-)

Confabula zei

Remko is back - en hoe!!

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